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The Buffalo Bills may have suffered a huge blow to their defense weeks before the start of training camp.

Linebacker Kiko Alonso suffered a knee injury during his preseason preparations.

“We have learned tonight that Kiko Alonso injured his knee while working out in Oregon,” said Bills general manager Doug Whaley in a statement Tuesday night. “We do not have the details at this point, but early indications are that it may be significant.”

Alonso was one of the top rookies in the league last season. He was taken in the second round of the NFL Draft by the Bills.