PHILADELPHIA — Without Donovan McNabb, the Philadelphia Eagles tried everything they could on offense. Drew Brees and the New Orleans Saints stuck to what they do best.

Brees tossed three more touchdown passes Sunday, helping the Saints beat Philadelphia, 48-22.

Brees had six TD passes last week as the Saints (2-0) routed Detroit, 45-27. He picked up where he left off, picking apart Philadelphia’s secondary and completing 25 of 34 passes for 311 yards and one interception.

The Saints visit Buffalo this Sunday.

“If you look at our skill group, each game no guy ever knows whose day it’s gonna be,” Brees said. “Each guy knows it’s their job to open things up for everyone else.”

Making his first NFL start for an injured McNabb, Kevin Kolb threw for 391 yards and two TDs, including a 71-yard scoring pass to DeSean Jackson. Kolb also threw three interceptions, though, including one returned 97 yards for a TD by Darren Sharper in the final minute.

“I’ve got to cut those turnovers out,” Kolb said. “I know better than that. I will do it.”

McNabb sat out with a cracked rib. With the five-time Pro Bowl QB in street clothes, the Eagles (1-1) showed off their creativity on offense.

Coach Andy Reid and offensive coordinator Marty Mornhinweg used several variations of the wildcat formation with three different players taking snaps. Both tackles were split wide one time with only three linemen blocking. Kolb threw an incomplete pass on a reverse flea flicker and Brian Westbrook had an incompletion.

It could get even wackier next week when Michael Vick is expected to play his first regular-season game since Dec. 31, 2006.

The Saints took advantage of a fumble recovery and interception to turn a four-point halftime lead into a 31-13 advantage in the first 3 1/2 minutes of the third quarter.

Ellis Hobbs fumbled the second-half kickoff and Chris Reis recovered at the Eagles

22. Two plays later, Brees tossed an 11-yard TD pass to fullback Heath Evans, who broke a couple of tackles and dove over the orange pylon.