The bacteria that cause acne live on everyone’s skin, yet one in five people is lucky enough to develop only an occasional pimple over a lifetime. What’s their secret?
In a boon for teenagers everywhere, a UCLA study conducted with researchers at Washington University in St. Louis and the Los Angeles Biomedical Research Institute has discovered that acne bacteria contain “bad” strains associated with pimples and “good” strains that may protect the skin.
The findings, published in the Journal of Investigative Dermatology, could lead to a myriad of new therapies to prevent and treat this disfiguring skin disorder.
“We learned that not all acne bacteria trigger pimples. One strain actually may help keep skin healthy,” explained lead author Huiying Li, an assistant professor of molecular and medical pharmacology at the David Geffen School of Medicine at the University of California-Los Angeles.
The scientists looked at a tiny microbe with a big name: Propionibacterium acnes, bacteria that thrive in the oily depths of our pores.
When the bacteria aggravate the immune system, they cause the swollen, red bumps associated with acne.
Using over-the-counter pore-cleansing strips, LA BioMed and UCLA researchers lifted P. acnes bacteria from the noses of 49 pimply and 52 clear-skinned volunteers.
After extracting the microbial DNA from the strips, Li’s laboratory tracked a genetic marker to identify the bacterial strains in each volunteer’s pores and recorded whether the person suffered from acne.
Next, Li’s lab cultured the bacteria from the strips to isolate more than 1,000 strains. Washington University scientists sequenced the genomes of 66 of the P. acnes strains, enabling UCLA co-first author Shuta Tomida to zero in on genes unique to each strain.
“We were interested to learn that the bacterial strains looked very different when taken from diseased skin, compared to healthy skin,” said co-author Dr. Noah Craft, a dermatologist and director of the Center for Immunotherapeutics Research at LA BioMed at Harbor-UCLA Medical Center.
“Two unique strains of P. acnes appeared in one out of five volunteers with acne but rarely occurred in clear-skinned people.”
The biggest discovery was still to come.
“We were extremely excited to uncover a third strain of P. acnes that’s common in healthy skin yet rarely found when acne is present,” said Li, who’s also a member of UCLA’s Crump Institute for Molecular Imaging. “We suspect that this strain contains a natural defense mechanism that enables it to recognize attackers and destroy them before they infect the bacterial cell.”
Offering new hope to acne sufferers, the researchers believe that increasing the body’s friendly strain of P. acnes through the use of a simple cream or lotion may help calm spotty complexions.