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David O. Russell’s “American Hustle” has won the Screen Actors Guild award for outstanding cast, setting up the con-artist comedy as the film to beat at the Academy Awards.

The other nominees Saturday night at the ceremony at Los Angeles’ Shrine Auditorium were “12 Years a Slave,” “Dallas Buyers Club,” “August: Osage County” and “Lee Daniels’ The Butler.” Because actors make up the largest branch of the Academy of Motion Picture Arts and Sciences, the SAG Awards are considered one of the most predictive tea leaves of the Oscars.

Saturday’s awards were a somewhat low-key affair with a few memorable speeches but no earthquakes in a rapidly solidifying award season. The night’s acting winners – Matthew McConaughey (“Dallas Buyers Club”), Cate Blanchett (“Blue Jasmine”), Lupita Nyong’o (“12 Years a Slave”) and Jared Leto (“Dallas Buyers Club”) – are each probably the favorites of their categories.

“It really shines a great light on this bull ride we call acting,” said McConaughey, honored for lead actor in the Texas HIV drama. “I’ve been able to recently find some characters that I can humble myself to their humanities and get feverishly drunk on their obsessions.”

Coming two days after Academy Award nominations, the SAG Awards are particularly monitored for predicting Oscar momentum. The outstanding cast category, the night’s top honor, was perhaps a showdown between “American Hustle” and “12 Years a Slave.” The two very different films were kept separated by drama and comedy categories at the Golden Globes.

Nyong’o won for supporting actress for her performance as the singular slave Patsy in Steve McQueen’s historical drama. She thanked McQueen “for taking a flashlight and shining it underneath the floorboards of this nation and reminding us what it is we stand on.”

The Kenyan actress, who has been hailed for her red-carpet grace this awards season, recalled her celebratory phone call to her father when she got the part – her first feature film.

“ ‘Daddy, do you know who Brad Pitt is? I’m going to be in a movie with him!’ ” recalled Nyong’o. “And he said, ‘I don’t know him personally, but I’m glad you got a job.’ ”

Leto was honored for supporting actor for playing the gaunt transsexual Rayon, alongside McConaughey’s Texas cowboy. He dedicated the award to those who have died of AIDS and to “the Rayons of the world.”

The “Breaking Bad” victory lap continued as the show took honors for outstanding dramatic cast and for lead actor Bryan Cranston. For his indelible performance as teacher-turned-meth dealer, Cranston added his second lead actor SAG Award, to go with his recent Golden Globe win and his numerous Emmys.

“We have the nicest bunch of white supremacist Nazis I have ever worked with,” said Cranston, looking over his former castmates. “I swear to you I would kill you all over again.”

Two big-screen veterans won awards for TV films: Michael Douglas for HBO’s Liberace drama “Behind the Candelabra,” and Helen Mirren for the biopic “Phil Spector,” also on HBO.

“I am not here without Matt Damon,” said Douglas, after making a gay sex pun that made his co-star wince.

Julia Louis-Dreyfus has been a mainstay at award shows recently, both for her acclaimed HBO series “Veep” (for which she won an Emmy) and the romantic comedy “Enough Said” (for which she was nominated for a Golden Globe). She won a SAG trophy for female actor in a comedy series for “Veep,” and slyly mocked the award season crush by first thanking the Hollywood Foreign Press and then the Academy of Motion Picture Arts & Sciences.

“It’s hard you know because it’s awards season and things get confusing, much like elections,” said Louis-Dreyfus.

The ABC sitcom “Modern Family” enjoyed another round of awards, winning for ensemble in a comedy series and taking the male actor in a comedy series honor for Ty Burrell.

SAG’s lifetime achievement award was given to Rita Moreno, the 81-year-old actress whose career has spanned Broadway, TV and music.