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NEW YORK (AP) Defending champion Andy Murray could face top-seeded Novak Djokovic only in the U.S. Open semifinals, while Rafael Nadal and Roger Federer who have never played each other at Flushing Meadows might meet in the quarterfinals.

Murray beat Djokovic in the 2012 final.

Thursday's draw for the year's last Grand Slam tournament also set up these possible men's quarterfinals: 2011 champion Djokovic vs. 2009 champion Juan Martin del Potro, No. 3 Murray vs. No. 5 Tomas Berdych, and No. 4 David Ferrer vs. No. 8 Richard Gasquet.

The potential women's quarterfinals are No. 1 Serena Williams against No. 8 Angelique Kerber, No. 2 Victoria Azarenka against No. 7 Petra Kvitova, No. 3 Agnieszka Radwanska against No. 5 Li Na, and No. 4 Sara Errani against No. 6 Caroline Wozniacki.