DURHAM, N.C. — Durham took a close game and blew it open in the fifth inning. The Bulls scored five runs to go up 6-2 and never looked back, defeating the Buffalo Bisons, 10-2, on Wednesday night.

The Bisons have lost three in a row, all to Durham. Buffalo fell to 28-23 and is second in the International League North.

Claudio Vargas (3-5) took the loss. Vargas went 4∑ innings and surrendered 10 hits and six earned runs.

Bisons manager Marty Brown was ejected for arguing a call in the sixth inning when Moises Sierra was called out at third base, to Brown’s chagrin.

The Bisons’ highlight of the night came when speedy shortstop Ryan Goins hit an inside-the-park home run in the top of the third inning.

Goins, Sierra and right fielder Ricardo Nanita had Buffalo’s only three hits.

Durham scored four insurance runs in the eighth inning.

Bulls reliever Adam Liberatore (1-1) got the win after going 2∏ innings.

Left fielder Jason Bourgeois led Durham with two hits, three RBIs and one run.

Durham jumped to a 1-0 lead in the first inning, and it stayed that way until Buffalo knotted it at 1 in the third and eventually took a 2-1 lead in the top of the fifth. That’s when the Bulls’ bats exploded for seven hits and five runs to take control.

Second baseman Jim Negrych, the Bisons’ offensive leader who is hitting .377 with three home runs and 24 RBIs, has not played in the series. The Bulls started left-handers in the first two games so Negrych sat, and he has also been nursing a minor muscle pull in his side. He could return tonight.

The teams will complete their four-game series tonight at 7:05.

Wednesday, the Blue Jays announced right-hander Thad Weber was sent to Buffalo. The team also called up right-handed pitcher Neil Wagner and left-hander Juan Perez from the Bisons.