1. Take a chance on some blitzes. The Bills might be the only team in the league to say they're unhappy to see Mark Sanchez, right, at quarterback. The Jets' starter had his best game of the season in Week One against the Bills, going 19 of 27 for 266 yards and throwing three touchdowns. It was downhill from there, though, until being benched prior to Week 16. Sanchez's replacement, former third-stringer Greg McElroy, was sacked 11 times against the Chargers last Sunday. Jets coach Rex Ryan called his team's pass protection as “poor as I can ever remember.” To get sacked 11 times, though, it's got to be a combination of things – McElroy holding the ball too long, a poor job by the offensive line, creative blitzing and receivers failing to get open. McElroy suffered a concussion in the loss, so the Bills will see Sanchez again. It'd be nice to see Bills defensive coordinator Dave Wannstedt dial up a few blitzes. After all, what does the team have to lose?

2. Get Mario Williams to show up. One of the low points in a season full of them for the Bills came in the opening loss when Williams, their high-profile free agent defensive end, was dominated by journeyman right tackle Austin Howard. Williams then made matters worse after the game by complaining about the replacement officials. After undergoing wrist surgery in the bye week, however, Williams' production greatly improved. He had seven sacks in a six-game stretch, but hasn't recorded one in the last two weeks. What's worse, Williams hasn't looked remotely interested. Bills expect – and deserve – more from NFL's richest-paid defensive player.

3. Find a pleasant surprise at receiver. The Bills will be without their second- and third-leading receivers, respectively, in Scott Chandler and Donald Jones. The Jets' pass defense is ranked second in the NFL, allowing just 187.4 yards per game. The Bills, though, should view this as an opportunity for players like rookie T.J. Graham and especially Marcus Easley to get some valuable playing experience. Stevie Johnson will likely draw Antonio Cromartie and have to work to get the 65 yards he needs to reach 1,000 for the third consecutive season.

4. Turn around the turnovers; win the ground game. The Bills and Jets have both been terrible in turnover differential. New York is a minus -13, which ranks 27th in the NFL, a spot ahead of the Bills at minus -14. One way the Bills can limit their risk is by feeding running back C.J. Spiller. Jets second-year defensive end Muhammad Wilkerson is questionable for the game because of a concussion, which only strengthens the case to give the ball to Spiller more. Wilkerson is the Jets' best interior defender, ranked third at his position by the website Still the Jets rank 27th against the run.The Bills are sixth in rushing.

5. Maintain some semblance of focus. Bills quarterback Ryan Fitzpatrick admitted that blocking out the “uncertainty” about what the immediate future will bring in regards to coaching and/or personnel changes has been difficult. That's not a surprise, since it's quite possibly the final game of his Bills career.

Outlook: Rex Ryan has had Chan Gailey's number, going 5-0 against the Bills' coach. Ryan should be able to keep that record perfect today.

Prediction: Jets 20, Bills 13