The bacterial zoo inside your gut could look very different if you’re a vegetarian or an Atkins dieter, a couch potato or an athlete, fat or thin.
Now for a fee – $69 and up – and a stool sample, the curious can find out just what’s living in their intestines and take part in one of the hottest new fields in science.
Wait a minute: How many average Joes really want to pay for the privilege of mailing such, er, intimate samples to scientists?
A lot, hope the researchers running two novel citizen-science projects.
One, the American Gut Project, aims to enroll 10,000 people – and a bunch of their dogs and cats, too – from around the country. The other, uBiome, separately aims to enroll nearly 2,000 people from anywhere in the world.
“We’re finally enabling people to realize the power and value of bacteria in our lives,” said microbiologist Jack Gilbert of the University of Chicago and Argonne National Laboratory. He’s one of a team of well-known scientists involved with the American Gut Project.
Don’t be squeamish: Yes, we share our bodies with trillions of microbes, living communities called microbiomes. Many of the bugs, especially those in the intestinal tract, play indispensable roles in keeping us healthy, from good digestion to a robust immune system.
But which combinations of bacteria seem to keep us healthy? Which ones might encourage problems like obesity, diabetes or irritable bowel syndrome?
And do diet and lifestyle affect those microbes in ways that we might control someday?
Answering those questions will require studying vast numbers of people. Getting started with a grass-roots movement makes sense, said National Institutes of Health microbiologist Lita Proctor, who isn’t involved with the new projects but is watching closely.
After all, there was much interest in the taxpayer-funded Human Microbiome Project, which last summer provided the first glimpse of what makes up a healthy bacterial community in a few hundred volunteers.
Proctor, who coordinated that project, had worried “there would be a real ick factor. That has not been the case,” she said. Many people “want to engage in improving their health.”
Scott Jackisch, a computer consultant in Oakland, Calif., ran across American Gut while exploring the science behind different diets, and signed up. He’s read with fascination earlier microbiome research: “Most of the genetic matter in what we consider ourselves is not human, and that’s crazy. I wanted to learn about that.”
Testing a single stool sample costs $99 in that project, but he picked a three-sample deal for $260 to compare his own bacterial makeup after eating various foods.
“I want to be extra, extra well,” said Jackisch, 42. Differing gut microbes may be the reason “there’s no one magic bullet of diet that people can eat and be healthy.”
It’s clear that people’s gut bacteria can change over time. What this new research could accomplish is a first look at how different diets may play a role, said American Gut lead researcher Rob Knight of the University of Colorado, Boulder.
One challenge is making sure participants don’t expect that a map of their gut bacteria can predict their future health or suggest lifestyle changes, anytime soon.
Participants can sign up for either project via the social fundraising site Indiegogo.com over the next month. They also can send scrapings from the skin, mouth and other sites, to analyze that bacteria. Sign up enough family members or body sites, or be tracked over time, and the price can rise into the thousands. American Gut researchers plan some free testing for those who can’t afford the fees, to try to increase the experiment’s diversity.
Don’t forget the pets: “We sleep with them, play with them, they often eat our food,” said American Gut co-founder Jeff Leach, an anthropologist. What bacteria we have in common is the next logical question.
Lauran Neergaard covers health and medical issues for the Associated Press in Washington.