The black mold creeping into the spines of hundreds of people who got tainted shots for back pain marks uncharted medical territory.
Never before has this particular fungus been found to cause meningitis. It’s incredibly hard to diagnose, and to kill – requiring at least three months of a treatment that can cause hallucinations. There’s no good way to predict survival, or when it’s safe to stop treating, or exactly how to monitor those who fear the fungus may be festering silently in their bodies.
“I don’t think there is a precedent for this kind of thing,” said Dr. Arjun Srinivasan of the Centers for Disease Control and Prevention. Health officials and doctors have tracked down most of the 14,000 people potentially at risk for fungal meningitis, blamed for the deaths of 24 people and sickening more than 300.
“This is definitely new territory for us,” he said.
The fungus’ brown-black color signals an armor that – along with being injected near the spine – helped this mold sneak past the immune defenses of otherwise healthy people, said Dr. Arturo Casadevall, a fungal disease specialist at New York’s Albert Einstein College of Medicine.
“What we’re dealing with here is fundamentally different” from a typical fungal infection, he said. “This is a bug that most of us don’t know much about.”
But they’re learning fast, piecing together clues that promise some hope.
Doctors are beginning to detail in medical journals the first deaths in this outbreak, and the grim autopsy findings make clear that treating early is crucial, before the fungus becomes entrenched. In one case, a woman died in Maryland after the fungus pierced blood vessels in her brain, leading to severe damage.
People getting treated earlier “seem to be doing OK,” with fewer of the strokes that characterized the outbreak’s beginning, said Dr. Carol Kauffman of the University of Michigan. She has advised the CDC and co-authored advice in the New England Journal of Medicine on how to handle the complex medication used in treatment.
People who got contaminated steroid shots made by a Massachusetts pharmacy have been told to be on guard for months for meningitis symptoms. But the CDC said that the biggest risk for getting sick seems to be within 42 days of receiving one of the implicated back injections.
With the tainted shots recalled in late September, that means the period of greatest risk is nearing an end. And it should help doctors bombarded with calls from the worried determine who most needs a spinal tap to look for the very earliest signs of infection.
The CDC said doctors have two valid options: To watch patients closely for symptoms or to consider a just-in-case spinal tap, possibly repeated weekly, for at-risk people still inside that 42-day window. However, CDC officials note that spinal taps come with their own risks.
“We know the farther out you are from receiving an injection, the lower your risk becomes for developing meningitis or other infections. We want to emphasize that,” CDC’s Dr. Tom Chiller told a conference call for physicians.
The main culprit in this outbreak is a black mold called Exserohilum rostratum, common in dirt and grasses. Only 33 human infections previously had been reported, mostly eye or skin infections in people with weak immune systems, Casadevall said.
The good news: Black mold is treatable with a drug named voriconazole, with far fewer side effects than the older treatment initially recommended when the outbreak began.
Still, Kauffman cautioned doctors to carefully monitor patients because differences in metabolism can make levels surge in the bloodstream, causing hallucinations, confusion, nausea and occasionally liver damage. On the flip side, their bodies may process the drug too quickly to battle the fungus. Plus, voriconazole can interact badly with a list of other common medications.
“It’s not clear” how long to treat but at least three months is advised, Kauffman said. It begins with intravenous infusions that are hard to administer outside of a hospital. Then once the patient is stable enough, pills can be used.
Associated Press Medical Writer Mike Stobbe in New York contributed to this report.